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Original Research Article | OPEN ACCESS

Synergistic anticancer and antibacterial activities of cordycepin and selected natural bioactive compounds

He Ni1, Rui-Lin Hao1, Xue-Feng Li1 , Vassilios Raikos2, Hai-Hang Li1,3

1Guangdong Provincial Key Lab of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou 510631; 2Rowett Institute, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK; 3Institute of Brain Science and Rehabilitation Medicine, South China Normal University, Guangzhou 510631, China.

For correspondence:-  Xue-Feng Li   Email: xa1209@163.com   Tel:+862085212630

Accepted: 29 July 2018        Published: 31 August 2018

Citation: Ni H, Hao R, Li X, Raikos V, Li H. Synergistic anticancer and antibacterial activities of cordycepin and selected natural bioactive compounds. Trop J Pharm Res 2018; 17(8):1621-1627 doi: 10.4314/tjpr.v17i8.22

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate if cordycepin (Cor) exerts synergistic anticancer and antibacterial activities with curcumin (Cur), resveratrol (Res), genistein (Gen), and anthocyanidin (Ant) in order to improve its therapeutic effect.
Methods: Antibacterial activity was assayed against Escherichia coli BL21 (DE3) cultured in the Luria-Bertani (LB) medium, while anticancer activity against Hela cells was determined using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Immunofluorescence assay was used to measure the expressions of p53 and caspase-3, while apoptosis was assayed in Hela cells using Wright-Giemsa dye staining method.
Results: The combination of Cor and Gen produced the most significant synergistic antibacterial activity, while combination of Cor, Cur and Gen exerted significant and synergistic anticancer activity against Hela cells. Among all three-compound combinations, Cor + Res + Gen had the highest synergistic anticancer activity. Immunofluorescence data indicate that Cor functioned by up-regulating p53-dependent apoptosis, while Res exerted its effect by p53- and caspase-3-dependent apoptosis, and Gen functioned by inhibiting adenosine deaminase and Cor degradation.
Conclusion: The three compounds function via different mechanisms, and synergistically induce Hela cell apoptosis. This work provides a strong basis for the development of highly active and multi-component anticancer drugs from natural sources.

Keywords: Cordycepin, Natural phenolic compounds, Caspase, Anticancer, Synergy

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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